Eric Bradley
Professor,
Biology
Ph.D.,
Biological Sciences, University of California, Santa Barbara
Office: Integrated
Science Center 1- 3048
Phone: 757 221 2220
Email: elbrad@wm.edu
Webpage: http://elbrad.people.wm.edu/
Research
Areas
We have studies underway in
collaboration with scientists in the departments of Applied Science, Biology,
and Physics, as well as the Thomas Jefferson Accelerator Facility to develop
very high resolution Single Photon Emission detectors. These detectors are used
in a dual modality imaging system with X-ray. We are developing the associated
Computed Tomography software and hardware for in vivo SPECT imaging of both
gene expression as well as for pharmacodynamic
studies of iodine-labeled ligands.
In addition, we are continuing
studies on the endocrine bases of reproductive inhibition. More specifically,
we have identified a mouse model system for reproductive inhibition that
resembles human stress-induced infertility. Our studies have centered on
determining the nature of a density-related and reversible reproductive
inhibition in two Peromyscus species. These studies
involve molecular and cellular approaches to determining the expression of
genes and the gene products that may contribute to and maintain reproductive
inhibition.
Current
Research Projects
Recent
Reports and Publications
Qian, Jianguo, Bradley, Eric L.,
Majewski, Stan, Popov, Vladimir, Saha, Margaret S.,
Smith, Mark F., Weisenberger, Andrew G., and Welsh, Robert E. (2008)
"A small-animal imaging system capable of multipinhole
circular/helical SPECT and parallel-hole SPECT." Nuclear
Instruments and Methods in Physics Research A 594 (2008) 102–110.
Hammond, WT., Bradley, EL., Welsh, RE., Qian, J.,
Weisenberger, AG., Smith, MF., Majewski,
S., Saha, MS, (2007) “A Gamma Camera Re-evaluation of Potassium Iodide Blocking
Efficiency in Mice.” Health Physics 92(4): 396-406.
Bradley, E.L., Cella, J., Majewski, S., Popov, V., Qian,
J., Saha M.S., Smith, M.F., Weisenberger, A.G., and Welsh, R.E.
(2006) A Compact Gamma Camera for Biological Imaging.
IEEE, Trans. Nucl. Sci.
53(1):59-65.
Saha, M.S., Bradley, E.L., Brewer, P., Gleason, K.K., Kross,
B., Majewski, S., Popov, V., Qian,
J., Ranck, A., Smith, K., Smith, M.F., Weisenberger,
A.G., Wojcik, R., and Welsh, R.E., (2003) An
Economical Dual-Modality Small Animal Imaging System with Application to
Studies of Diabetes. IEEE Transactions on Nuclear Science 50(3): 333-38.
Weisenberger, A.G., Wojcik, R.,
Bradley, E.L., Brewer, P., Majewski, S., Qian, J., Ranck, A., Saha, M.S.,
Smith, M.F., and Welsh, R.E. (2003) SPECT-CT System for Small Animal Imaging.
IEEE Transactions on Nuclear Science 50(1): 74-79.
Cherry, B.A., Cadigan, B., Mansourian,
N., Nelson, C., and Bradley, E.L. (2002) Adrenal gland differences associated
with puberty and reproductive inhibition in Peromyscus
maniculatus. Gen. Comp. Endocrinology
129:104-113.
In vivo imaging of the Distribution and Pharmacodynamics of 125 Iodine-labeled Insulin During the
Development of Streptozotocin-Induced Hyperglycemia
in the C57BL/6J Mouse with a Dedicated Gamma Imager. Bradley, E.L.,
Gleason K.K., Majewski, S., Ranck
A.E., Saha, M.S., Smith, M.F., Weisenberger, A.G., Welsh, R.E., and Wojcik, R. High Resolution Imaging in Small Animals. 9-11 September 2001, Rockville MD.
Development of a Minature SPECT-CT
System for Small Animal Imaging. Weisenberger, A.G., Bradley, E.L., Majewski, S., Saha, M.S., Smith, M.F., Welsh, R.E., and Wojcik, R. High Resolution Imaging in Small Animals. 9-11 September 2001, Rockville MD.
Experimental Results and Predictive Calculations for Pinhole
Collimators Used in Small Animal Nuclear Imaging. Ng, L., Ranck, A., Feldmann, J., Welsh,
R. E., Bradley, E.L., Saha, M.S., Smith, M., Kross,
B., Popov, V., Weisenberger, A.and Wojcik, R. American Physical Society, Annual Meeting, April
2001, Wash. DC.
A Novel Technique for Coregistration
of Biological Images in a Multimodality Detector Array. Ranck, A., Feldmann, J., Robert
E. Welsh, Bradley, E.L. Saha, M.S., Kross, B., Popov,
V., Weisenberger, A. and Wojcik, R. American Physical
Society, Southeastern Section, November 2000.
Dual-Modality Small Animal Imaging System. Ranck, A., Feldmann, J.,
Saunders, R.S., Welsh, R.E., E.L., Saha, M.S., Kross,
B., Popov, V., Weisenberger, A. and Wojcik, R.
American Physical Society, Division of Nuclear Physics, General Meeting,
October 2000.
Single Photon Computed Tomography With Large
Position-Sensitive Phototubes. Feldmann, J., Ranck, A., Saunders, R.S., Welsh, R.E., Bradley, Saha,
M.S., Kross, B., Popov, V., Weisenberger, A., and Wojcik, R. American Physical Society, Division of Nuclear
Physics, General Meeting, October 2000.
Weisenberger, A., E. Bradley, S. Majewski,
and M. Saha. 1998. Development of a novel radiation imaging detector
system for in vivo gene imaging in small animal studies. IEEE Transactions
on Nuclear Science 45(3): 1743-1749.
Staubs,
P.A. and E.L. Bradley. 1998. Oxygen consumption and carbon dioxide
production in male Prairie Deermice in different
reproductive conditions and group densities. Comp. Biochem.
Physiol. 119A: 287-294.
Weisenberger, A., B. Kross, S. Majewski, S. Wojcik, E. Bradley,
and S. Saha. 1998. Design features and performance of a CsI(Na)
array based gamma camera for small animal gene research. IEEE Transactions
on Nuclear Science 45(6): 3053-3058.
Weisenberger, A.G., S. Majewski, M.
Saha and, E. Bradley. 1997. Coincident radiation imaging of idoine 125 for in vivo gene imaging in small animals. Nuclear
Instruments and Methods in Physics Research A 392: 299-303.
Last updated 7/1/09